منابع مشابه
Macrophage-lymphocyte Interaction
The nature of the physical interaction between guinea pig non-glass-adherent lymphoid cells and syngeneic macrophages in vitro was investigated. This cellular interaction was found to require the presence of metabolically intact macrophages but neither serum nor antigen. Peritoneal, splenic, or alveolar macrophages were significantly more capable of interacting with thymocytes than either polym...
متن کاملSecretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.
In this study we show that T cells from mice infected with Listeria monocytogenes can interact in vitro with normal macrophages to produce a number of soluble mediators, including lymphostimulatory molecules. One of these molecules was a 15,000-dalton protein mitogenic for thymocytes. Generation of mitogenic activity was essentially completed by the first 24 hr of culture and did not require th...
متن کاملT lymphocyte and monocyte-macrophage interaction in colony-stimulating activity elaboration in man.
Using in vitro culture systems. we have studied the effect of coincubating human monocyte-macrophages with autologous T lymphocytes on colony-stimulating activity (CSA) elaboration in response to methanol extraction residue (MER) of BCG. When monocyte-macrophages were coincubated with T lymphocytes for 4 days at a ratio of 1 :3. the resultant colony-stimulating activity. assayed against light d...
متن کاملThe role of I region gene products in macrophage - T lymphocyte interaction.
The macrophage first gained recognition in the early 192O's and 193O's as the cell responsible for clearing antigen and synthesizing antibody (Sabin 1923). Its importance to the immune response faded with the realization that lymphocytes and not macrophages were the origin of antibody molecules and it was not until the early 196O's that experiments suggested that antigen processing by the macro...
متن کاملMacrophage-lymphocyte clustering in rheumatoid arthritis.
The cells in synovial fluid from patients with rheumatoid arthritis contain a small percentage of macrophages. Such macrophages were isolated and cultured alone and with homologous and heterologous lymphocytes for 24 hours, in an attempt to identify possible contact between living lymphocytes and macrophages. Such contact was found, with clustering of lymphocytes around macrophages, and was par...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.138.4.900